Patients with atopic dermatitis (AD) have higher odds of depression and suicidality, according to a recent investigation. A systematic review of all published observational studies in databases that analyzed depression in AD was performed. 2 reviewers performed study title and/or abstract review and data abstraction. Pooled meta-analysis was performed by using random-effects weighting. They found:
- Overall, 106 studies met the inclusion criteria; 36 had sufficient data for meta-analysis.
- The prevalence of any depression was higher in persons with vs without AD (20.1% vs 14.8%).
- Similar results were found in sensitivity analyses of studies assessing clinical depression, depressive symptoms, and adults; studies with healthy controls; and studies of low and high study quality.
- AD was associated with significantly higher depression scale scores, parental depression, antidepressant use, and suicidality.
Patel KR, Immaneni S, Singam V, Rastogi S, Silverberg JI. Association between atopic dermatitis, depression, and suicidal ideation: A systematic review and meta-analysis. J Am Acad Dermatol. 2019;80(2):402–410. doi:10.1016/j.jaad.2018.08.063.