Leukocyte telomere length (LTL) reflects prenatal stress exposure but does not predict atopic dermatitis (AD) development at 1 year, a new study found. From a birth cohort, researchers selected 68 pairs of samples from 4 subject groups based on the level of prenatal maternal stress and later AD development. The LTL was measured from both cord blood and 1-year peripheral blood. Patient LTLs were compared between groups. Among the findings:
- Cord-blood LTL was shorter in prenatally stressed vs unstressed infants, which difference was still significant at age 1 year.
- LTL of cord blood, as well as 1 of the 1-year peripheral blood, was not different according to later AD development at 1 year.
- Shorter LTL made no increase in the proportion of later AD development in either group.
Suh DI, Kang MJ, Park YM, et al. Leukocyte telomere length reflects prenatal stress exposure, but does not predict atopic dermatitis development at 1 year. Allergy Asthma Immunol Res. 2019;11(3):357-366. doi:10.4168/aair.2019.11.3.357.