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Leukocyte Telomere Length & AD Development

Leukocyte telomere length (LTL) reflects prenatal stress exposure but does not predict atopic dermatitis (AD) development at 1 year, a new study found. From a birth cohort, researchers selected 68 pairs of samples from 4 subject groups based on the level of prenatal maternal stress and later AD development. The LTL was measured from both cord blood and 1-year peripheral blood. Patient LTLs were compared between groups. Among the findings:

  • Cord-blood LTL was shorter in prenatally stressed vs unstressed infants, which difference was still significant at age 1 year.
  • LTL of cord blood, as well as 1 of the 1-year peripheral blood, was not different according to later AD development at 1 year.
  • Shorter LTL made no increase in the proportion of later AD development in either group.

Citation:

Suh DI, Kang MJ, Park YM, et al. Leukocyte telomere length reflects prenatal stress exposure, but does not predict atopic dermatitis development at 1 year. Allergy Asthma Immunol Res. 2019;11(3):357-366. doi:10.4168/aair.2019.11.3.357.