Key clinical point: Children with both atopic dermatitis and food allergy can be distinguished from those with just atopic dermatitis via their nonlesional skin surface.
Major finding: Those in the AD FA+ group were found to have “a constellation of stratum corneum attributes,” including increased TEWL and lower levels of filaggrin gene breakdown products.
Study details: A prospective clinical study of 62 children aged 4-17 years who were divided into three groups: atopic dermatitis and food allergy, atopic dermatitis and no food allergy, and nonatopic controls.
Disclosures: The study was funded by the National Institute of Health/The National Institute of Allergy and Infectious Diseases’ Atopic Dermatitis Research Network, with partial support from the Edelstein Family Chair for Pediatric Allergy at NIH and a NIH/National Center for Advancing Translational Sciences Colorado Clinical and Translational Science Awards grant. Three of the authors declared being inventors of a patent that covers methods of identifying AD with FA as a unique endotype. No other conflicts of interest were reported.
Leung DYM et al. Sci Transl Med. 2019 Feb 20. doi: 10.1126/scitranslmed.aav2685.