Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Eye Problems May Signal Zika Infection

JAMA Pediatr; ePub 2017 Jul 17; Zin, et al

Any infant who may have been exposed to the Zika virus through maternal transmission should have an eye exam, as ophthalmic abnormalities may be the only initial indication that the child has been infected, according to an international team of experts. Their findings include the following:

  • A case series that included 112 infants born to mothers with confirmed Zika infection found 24 had eye problems (21.4%).
  • 10 of these infants did not have microcephaly and 8 didn’t have any central nervous system complications.


Zin AA, Tsui R, Rossetto J, et al. Screening criteria for ophthalmic manifestations of congenital Zika virus infection. [Published online ahead of print July 17, 2017]. JAMA Pediatr. doi:10.1001/jamapediatrics.2017.1474.