A new way to treat ear infections in children called "individualized care" is described in the May 2013 issue of Pediatric Infectious Diseases Journal. It explains how to reduce the frequency of repeated ear infections nearly 500% and how to reduce the need for ear tube surgery by 600% in your practice.
Dr. Janet Casey at Legacy Pediatrics in Rochester, N.Y.; Anthony Almudevar, Ph.D., of the University of Rochester; and I conducted the prospective, longitudinal multiyear study with the support of the National Institutes of Health’s National Institute for Deafness and Communication Disorders and the Thrasher Research Fund (Pediatr. Infect. Dis. J. 2013 Jan. 21 [Epub ahead of print]).
The study compared three groups: children who were in the Legacy Pediatrics practice and received individualized care; control children in the Legacy practice who did not participate because their parents declined participation (they did not want venipunctures or ear taps); and community controls drawn from a different pediatric practice in the suburbs of Rochester that used the diagnostic criteria of the American Academy of Pediatrics and treated all children empirically with high-dose amoxicillin as endorsed by the former and new AAP treatment guidelines (Pediatrics 2013;131:e964-99).
The new treatment paradigm of individualized care included a tympanocentesis procedure, also called an ear tap, to determine precisely the bacteria causing the ear infection. Treatment was started with high-dose amoxicillin/clavulanate. The sample of fluid then was taken to my laboratory at the Rochester General Hospital Research Institute, where the bacteria isolated were tested against a panel of antibiotics to determine whether to continue with amoxicillin/clavulanate or switch to a more effective antibiotic for the child based on culture susceptibility. By doing the ear tap and antibiotic testing, the frequency of repeated ear infections was reduced by 250%, compared with the Legacy practice controls who did not participate, and by 460%, compared with the community controls.
The most common reason for children to receive ear tubes is repeated ear infections, so when the frequency of ear infections was reduced so too was the frequency of ear tube surgery. The new treatment approach resulted in 260% fewer ear tube surgeries in the individualized care group, compared with the Legacy Pediatrics controls, and 620% fewer surgeries than the community controls.
Allowing the child to receive an ear tap was a requirement for the study. Dr. Casey and I found a way to do the procedure painlessly by instilling 8% Novocain in the ear canal as drops to anesthetize the tympanic membrane. After 15 minutes there was no pain when the tap was done. We used a papoose to hold the child still.
The ear-tap procedure not only allowed individualized care with the astonishing results reported, it also allowed more rapid healing of the ear since removal of the pus and bacteria from behind the ear allowed the antibiotics to work better and the immune system to clear the infection more effectively.
The article discusses reasons for the remarkable difference in results with the individualized care approach. First, Dr. Casey and I have undergone special training from ear, nose, and throat (ENT) doctors in the diagnosis of ear infections.
In earlier studies, a group of experts in otitis media diagnosis joined together in a continuing medical education course sponsored by Outcomes Management Education Workshops to use video exams to test whether pediatricians, family physicians, and urgent care physicians knew how to correctly distinguish true acute otitis media (AOM) from otitis media with effusion (OME) and variations of normal in the tympanic membrane exam. We found that all three specialty groups and residents in training in all three specialties and nurse practitioners and physician assistants overdiagnosed AOM about half the time.
Second, the selection of antibiotic proved to be key. Dr. Casey and I have the only otitis media research center in the United States providing tympanocentesis data at the current time. We have found that amoxicillin kills the bacteria causing AOM infections in children in the Rochester area only about 30% of the time. By knowing the bacteria, an evidence-based antibiotic can be chosen.
I expect that readers of this column will believe they diagnose AOM correctly nearly all the time and that it is the other physician who overdiagnoses. I expect that readers will be reluctant to not adhere to the AAP guideline recommendation of using amoxicillin as the treatment of first choice. Most of all, I expect readers to be reluctant to undertake training on how to do the ear tap procedure. Change is always resisted by the majority, and only with time does it occur if the evidence is strong and there is growing adoption.