Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Residential Lead Interventions’ Effect on Children

JAMA Pediatrics; ePub 2018 Aug 27; Braun, et al

Residential lead exposures, as well as blood lead concentrations in non-Hispanic black children, were reduced through a comprehensive lead-hazard intervention without elevating the lead body burden, according to a recent, randomized clinical trial of pregnant women and their children. This decrease, however, did not result in substantive neurobehavioral improvements in children. Pregnant women attending 1 of 9 prenatal care clinics were recruited. Of 1,263 eligible women, 468 (37.0%) agreed to participate and 355 women (75.8%) were randomized in this intention-to-treat analysis. Participants were randomly assigned to receive 1 of 2 interventions designed to reduce residential lead or injury hazards. Follow-up on children took place at 1, 2, 3, 4, 5, and 8 years of age. Researchers found:

  • The intervention did not statistically significantly reduce childhood blood lead concentrations.
  • Neurobehavioral test scores were not statistically different between children in the intervention group than those in the control group except for a reduction in anxiety scores in the intervention group.

Braun JM, Hornung R, Chen A, et al. Effect of residential lead-hazard interventions on childhood blood lead concentrations and neurobehavioral outcomes. A randomized clinical trial. [Published online ahead of print August 27, 2018]. JAMA Pediatrics. doi:10.1001/jamapediatrics.2018.2382.

This Week's Must Reads

AAP Updates Recommendations for Flu Vaccine, Pediatrics; 2018 Sep; Committee on Infectious Diseases

Local, National Vaccine Coverage of US Adolescents, MMWR; 2018 Aug 24; Walker, Elam-Evans, et al

Vaccine Information Sought 6 Weeks Post-Delivery , J Pediatr; ePub 2018 Sep 5; O’Leary, et al

Facebook HPV Vaccine Campaign Falls Short on Uptake, Vaccine; ePub 2018 Aug 29; Mohanty, Leader, et al

Viral Etiology of AGE in Post-Rotavirus Vaccine Era, J Pediatr Infect Dis Soc; ePub 2018 Sep 3; Hassan, et al

Must Reads in Mental Health

Discrimination Concern, Behavioral Issues Linked, JAMA Pediatrics; ePub 2018 Aug 20; Leventhal, et al

Residential Lead Interventions’ Effect on Children, JAMA Pediatrics; ePub 2018 Aug 27; Braun, et al

NAS Linked with Childhood Educational Disabilities, Pediatrics; ePub 2018 Aug 30; Fill, Miller, et al

QoL Assessed Among Children Born Extremely Preterm , J Pediatr; ePub 2018 Aug 2; Bangma, Kwiatkowski, et al

Parental Incarceration’s Effect on Young Adults, Pediatrics; ePub 2018 Jul 9; Heard-Garris, et al