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Cognitive Dysfunction Among Preterm Youth with BPD

Pediatrics; ePub 2018 May 17; Sriram, Schreiber, et al

Among 10-year-old children born extremely preterm, those who had bronchopulmonary dysplasia (BPD) were at increased risk of cognitive, language, and executive dysfunctions, as well as academic achievement limitations, social skill deficits, and low scores on assessments of health-related quality of life, according to a recent study. The study population included 863 children born extremely preterm whose BPD status before discharge was known had an IQ (Differential Ability Scales II [DAS II]) assessment at 10 years. Researchers evaluated the association of BPD with any cognitive (DAS II), executive function (NEuroPSYchological Assessment II), academic achievement (Wechsler Individual Achievement Test-III and Oral and Written Language Scales [OWLS]) as well as social dysfunctions (Social Responsiveness Scale). They found:

  • 372 (43%) children were oxygen-dependent at 36 weeks postconception age, whereas an additional 78 (9%) were also oxygen- and ventilator-dependent.
  • IQ scores ≥2 standard deviations below the expected mean (ie, z scores ≤−2) occurred twice as commonly among children who had BPD as among those who did not.
  • Children with severe BPD consistently had the lowest scores on DAS II, OWLS, Wechsler Individual Achievement Test-III, NEuroPSYchological Assessment II, and Social Responsiveness Scale assessments.


Sriram S, Schreiber MD, Msall ME, for the ELGAN Study Investigators. Cognitive development and quality of life associated with BPD in 10-year-olds born preterm. [Published online ahead of print May 17, 2018]. Pediatrics. doi:10.1542/peds.2017-2719.

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