Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Six factors predict urothelial cancer response

Pond GR et al. GU Cancers Symposium Abstract 413

Key clinical point: A six-factor model predicts overall survival in patients with advanced urothelial carcinoma given atezolizumab in the postplatinum setting.

Major finding: Median overall survival for patients with 0-1, 2-3, and 4 or more factors was 19.6, 5.9, and 2.8 months in the development cohort, and 19.4, 7.2 and 2.6 months in the validation cohort, respectively.

Data source: A study among patients given atezolizumab for advanced urothelial carcinoma with a development cohort (310 patients from the phase 2 IMvigor210 trial) and a validation cohort (95 patients from the phase 1 PCD4989g trial).

Disclosures: Dr. Pond disclosed that an immediate family member is an employee of Roche Canada. Genentech provided data for this study.

Source: Pond GR et al. GU Cancers Symposium Abstract 413

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Pond GR et al. GU Cancers Symposium Abstract 413

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