Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Selecting chemoradiation in bladder cancer

Coen, J. et al, 2018 Genitourinary Cancers Symposium, Abstract 408.

Key clinical point: Two concurrent chemoradiation induction regimens have similar efficacy in patients with muscle-invasive bladder cancer.

Major finding: The rate of freedom from distant metastasis at 3 years was 77.8% with twice-daily radiation plus 5-flourouracil-cisplatin and 84.0% with daily radiation plus gemcitabine.

Data source: A multicenter randomized phase 2 trial among 70 patients with muscle-invasive (cT2-4a) bladder cancer who had undergone TURBT (NRG/RTOG 0712 trial).

Disclosures: Dr. Coen disclosed that he had no relevant conflicts of interest. The trial was supported by the National Cancer Institute.

Source: Coen, J. et al, 2018 Genitourinary Cancers Symposium, Abstract 408.

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Coen, J. et al, 2018 Genitourinary Cancers Symposium, Abstract 408.

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