Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Selecting chemoradiation in bladder cancer

Coen, J. et al, 2018 Genitourinary Cancers Symposium, Abstract 408.

Key clinical point: Two concurrent chemoradiation induction regimens have similar efficacy in patients with muscle-invasive bladder cancer.

Major finding: The rate of freedom from distant metastasis at 3 years was 77.8% with twice-daily radiation plus 5-flourouracil-cisplatin and 84.0% with daily radiation plus gemcitabine.

Data source: A multicenter randomized phase 2 trial among 70 patients with muscle-invasive (cT2-4a) bladder cancer who had undergone TURBT (NRG/RTOG 0712 trial).

Disclosures: Dr. Coen disclosed that he had no relevant conflicts of interest. The trial was supported by the National Cancer Institute.

Source: Coen, J. et al, 2018 Genitourinary Cancers Symposium, Abstract 408.

Read the full article.

Citation:

Coen, J. et al, 2018 Genitourinary Cancers Symposium, Abstract 408.

This Week's Must Reads

New MOC pathway developed by ABIM, ASCO, Alternative to focus on oncology expertise

Survey indicates opioid prescriptions have decreased , Physicians' progress to reverse the nation's opioid epidemic. American Medical Association.

Oncologists sue over Medicare drug pay cut, Community Oncology Alliance v. Office of Management and Budget et al. ​

Gender disparity found in oncology research funding, Zhou CD et al. BMJ Open. 2018 Apr 30. doi: 10.1136/bmjopen-2017-018625

Trump administration rejects ACA lawsuit, Texas v. The United States centers on the individual mandate

Must Reads in Renal Cell Carcinoma

Risk categories predict mRCC survival, Rini B et al. Clin Genitourin Cancer. 2018 May 3. doi: 10.1016/j.clgc.2018.04.005.

Access to care linked to better outcomes in black men with prostate cancer, Halabi et al, George et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology) Abstracts LBA5005 and LBA5009.

Prostate cancer before age 55 more likely in black men, Nettey OS et al. AUA 2018 (American Urological Association annual meeting). Abstract MP 21-17.

Statins may affect prostate cancer microenvironment, Allott E et al. AUA 2018 (annual meeting of the American Urological Association), Abstract MP21-01.

Prostate cancer risks higher in smokers, Foerster B et al. JAMA Oncol. 2018 May 24. doi: 10.1001/jamaoncol.2018.1071.