Key clinical point: Red cell distribution width before treatment might be a quick and easy method for predicting cancer-specific survival in patients who undergo nephrectomy for renal cell carcinoma (RCC). Pretreatment red cell distribution width was associated with tumor necrosis and might be useful in the assessment of tumor aggressiveness.
Major finding: There were no differences between subjects with high and low red cell distribution width in terms of sex, age, body mass index, histological type of tumor, frequency of partial nephrectomy, and TNM stage. Patients with high red cell distribution width had significantly lower hematocrit, hemoglobin level, and red blood cell count. Tumor necrosis and larger tumor size were significantly more prevalent in the group of patients with high red cell distribution width. Cancer-specific survival was significantly lower in patients with red cell distribution width of 13.9% or more as compared with patients with red cell distribution width of less than 13.9%.
Study details: A study of 434 patients with pathologically proven RCC treated with radical or partial nephrectomy over a 10-year period in a single tertiary academic center. Patients were divided into 2 groups, with low and high red cell distribution width according to the optimal cutoff value, which was determined according to a receiver operating characteristic (ROC) curve. Median follow-up was 2146 days.
Disclosures: The authors have stated that they have no conflicts of interest.
Source: Życzkowski M et al. Clinical Genitourinary Surgery 2018 June (16), e677-e683. https://doi.org/10.1016/j.clgc.2017.12.003
Życzkowski M et al. Clinical Genitourinary Surgery 2018 June (16), e677-e683. https://doi.org/10.1016/j.clgc.2017.12.003
This Week's Must Reads
Perioperative radiation therapy underused in elderly patients with soft tissue sarcomas, Venigalla S et al. Intl J Rad Oncology*Biology*Physics; September (102) 2018: 155-165. https://doi.org/10.1016/j.ijrobp.2018.05.019
Age, R0 resection, and adjuvant radiotherapy boost outcomes in myxofibrosarcoma, Boughzala-Bennadji R et al. Intl J Rad Oncology*Biology*Physics; October (102) 2018: 399-406. https://doi.org/10.1016/j.ijrobp.2018.05.055
Tumor size, invasion beyond subcutaneous fat predict adverse outcomes in undifferentiated pleomorphic sarcoma, Winchester D et al. J Am Acad Dermatol. Available online 19 May 2018 https://doi.org/10.1016/j.jaad.2018.05.022
High recurrence rate after pancreaticoduodenectomy for primary retroperitoneal sarcoma, Tseng W et al. European Journal of Surgical Oncology 2018 (44): June; 810-815.
Nivolumab, pembrolizumab successfully used in Kaposi sarcoma, Galanina et al. Cancer Immunol Res. 2018 Sept 7. doi: 10.1158/2326-6066.CIR-18-0121.
Must Reads in Renal Cell Carcinoma
In mRCC: Sunitinib alone not inferior to nephrectomy-sunitinib, Méjean A et al. N Engl J Med. 2018 Aug 2. doi: 10.1056/NEJMoa1803675.
Proactive management eases side effects of sunitinib treatment in RCC, Staehler M et al. Ann Oncol. 2018 Aug 23. doi: 10.1093/annonc/mdy329
Red cell distribution width might predict cancer-specific survival in RCC , Życzkowski M et al. Clinical Genitourinary Cancer 2018 June (16), e677-e683. https://doi.org/10.1016/j.clgc.2017.12.003
mRCC: Patients survive longer at high-volume centers, Joshi SS et al. Euro Urol. 2018 Sep;74:387-93.
High PD1 mRNA levels tied to anti-PD1 monotherapy response, Paré L et al. Ann Oncol. 2018 Aug 27. doi: 10.1093/annonc/mdy335.