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Predicting RCC Outcomes After Surgery

Eur Urol; ePub 2018 Feb 2; Leibovich, et al

It appears possible to predict renal cell carcinoma (RCC) progression and death using readily available clinical and pathologic features, researchers concluded after conducting a retrospective cohort review involving >3,600 individuals. Participants had clear cell RCC (ccRCC; n=2,726), papillary RCC (papRCC; n=607), or chromophobe RCC (chrRCC; n=222). Investigators developed models based on clinicopathologic features to predict oncologic outcomes. Among the results:

  • Progression-free survival c-index was 0.83 for ccRCC, 0.77 for papRCC, and 0.78 for chrRCC.
  • Cancer-specific survival c-indexes were 0.86 for ccRCC and 0.83 for papRCC.
  • Due to only 22 deaths from RCC, cancer-specific survival was not assessed for chrRCC.
Citation:

Leibovich B, Lohse C, Cheville J, et al. Predicting oncologic outcomes in renal cell carcinoma after surgery. [Published online ahead of print February 2, 2018]. Eur Urol. doi:10.1016/j.eururo.2018.01.005.

This Week's Must Reads

Overall survival factor in metastatic ccRCC, Thiery-Vuillemin A et al. Clinical Genitourinary Cancer 2018; 16: e297-e305

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AXL linked to worse outcome of metastatic RCCs treated with sunitinib, Zucca L E et al. Urologic Oncology: Seminars and Original Investigations 2018: 36; 11.e13-11.e21

Pathologic predictors in lymph node dissection of metastatic RCC, Chipollini J et al. Clinical Genitourinary Cancer 2018; 16: Pages e443-450.

Plated-lymphocyte ratio is correlated with poor prognosis in RCC, Wang Z et al. Clinica Chimica Acta; 2018; 480: 166-72.

Must Reads in Renal Cell Carcinoma

Overall survival factor in metastatic ccRCC, Thiery-Vuillemin A et al. Clinical Genitourinary Cancer 2018; 16: e297-e305

High perirenal fat thickness predicts poor progression-free survival in patients with localized ccRCC, Huang H et al. Urologic Oncology: Seminars and Original Investigations 2018; 36: 157.e1-157.e6

AXL linked to worse outcome of metastatic RCCs treated with sunitinib, Zucca L E et al. Urologic Oncology: Seminars and Original Investigations 2018: 36; 11.e13-11.e21

Pathologic predictors in lymph node dissection of metastatic RCC, Chipollini J et al. Clinical Genitourinary Cancer 2018; 16: Pages e443-450.

Plated-lymphocyte ratio is correlated with poor prognosis in RCC, Wang Z et al. Clinica Chimica Acta; 2018; 480: 166-72.