Key clinical point: Patients with a history of renal cell carcinoma have a substantially increased risk of developing myelodysplastic syndromes as compared to the general population. Given the strong association, an unexplained cytopenia in patients with a history of nephrectomy for localized RCC would warrant a strong consideration for a bone marrow biopsy to detect myelodysplasia.
Major finding: The prevalence of myelodysplastic syndromes in patients over 65 years old with a history of nephrectomy for RCC was 8.4 times that of the age-concordant general population based on the Dusseldorf registry (28/6490 or 395/100,000 vs. 47/100,000), and 3.07 times that of the age-concordant patient population at Mayo Clinic (28/6490 or 395/100,000 vs 128.4/100,000. Both differences were statistically significant (P less than 0.001).
Study details: Mayo Clinic’s ‘Advanced Cohort Explorer’ database was used to identify patients with a history of both malignancies. Prevalence of myelodysplastic syndromes was noted in patients aged 65 years and older with a history of nephrectomy for RCC and was compared to the prevalence of myelodysplastic syndromes in the Dusseldorf MDS registry and the general patient population at Mayo Clinic.
Disclosures: The authors had no relevant financial disclosures.
Shenoy N et al. Clinical Genitourinary Cancer, Published online June 28, 2018. https://doi.org/10.1016/j.clgc.2018.06.008
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Pembrolizumab in advanced clear cell RCC, McDermott DF et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology), Abstract 4500.
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