Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

mRCC: Patients survive longer at high-volume centers

Joshi SS et al. Euro Urol. 2018 Sep;74[3]:387-93.

Key clinical point: Patients with metastatic renal cell carcinoma had significantly longer survival when they were treated at higher-volume centers.

Major finding: Overall survival was significantly longer among patients treated at centers with a mean of 20 vs. 5 or 10 cases per year, across all cohorts.

Study details: A retrospective study of National Cancer Database data on 41,836 patients with mRCC treated from 2004 through 2013.

Disclosures: The investigators did not specify a study funding source. Dr. Geynisman reported having no conflicts of interest.

Read the article.

Citation:

Joshi SS et al. Euro Urol. 2018 Sep;74[3]:387-93.

This Week's Must Reads

New model guides treatment decisions in mRCC, Armstrong AJ et al. Ann Oncol. 2018 Sep 10. doi: 10.1093/annonc/mdy406

mRCC: Jaw osteonecrosis increased with denosumab/antiangiogenics, Guillot A et al. Clin Genitourin Cancer. 2018 Sep 6. doi: 10.1016/j.clgc.2018.08.006.

Brazilian study: TKIs effective in clear cell RCC, Velho PI et al. J Glob Onc. 2018 Sep 10. doi: 10.1200/JGO.18.00073.

SBRT safe, effective in oligometastatic RCC, Franzese et al. J Urol. 2018 Sep 1. doi: 10.1016/j.juro.2018.08.049.

CRP levels and RCC prognosis, Nakayama T et al. Clin Genitourin Cancer. 2018 Aug 11. doi: 10.1016/j.clgc.2018.07.027.

Must Reads in Renal Cell Carcinoma

New model guides treatment decisions in mRCC, Armstrong AJ et al. Ann Oncol. 2018 Sep 10. doi: 10.1093/annonc/mdy406

mRCC: Jaw osteonecrosis increased with denosumab/antiangiogenics, Guillot A et al. Clin Genitourin Cancer. 2018 Sep 6. doi: 10.1016/j.clgc.2018.08.006.

Brazilian study: TKIs effective in clear cell RCC, Velho PI et al. J Glob Onc. 2018 Sep 10. doi: 10.1200/JGO.18.00073.

SBRT safe, effective in oligometastatic RCC, Franzese et al. J Urol. 2018 Sep 1. doi: 10.1016/j.juro.2018.08.049.

CRP levels and RCC prognosis, Nakayama T et al. Clin Genitourin Cancer. 2018 Aug 11. doi: 10.1016/j.clgc.2018.07.027.