Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Chemo is best course in resected urothelial disease

Birtle A et al. Genitourinary Cancers Symposium. Abstract 407.

Key clinical point: Chemotherapy is superior to surveillance for patients with resected upper-tract urothelial cancer.

Major finding: Compared with surveillance, adjuvant chemotherapy halved risk of disease-free survival events (hazard ratio, 0.49; P=.001).

Data source: A phase 3 randomized trial of adjuvant platinum-based chemotherapy versus surveillance in 261 patients with upper-tract urothelial cancer (POUT trial).

Disclosures: Dr. Birtle disclosed that she receives honoraria from Roche, Janssen, Astellas, and Bayer, and is a consultant to Sanofi-Aventis. The trial was funded by the UK Clinical Trials Awards and Advisory Committee.

Source: Birtle A et al. Genitourinary Cancers Symposium. Abstract 407.


Birtle A et al. Genitourinary Cancers Symposium. Abstract 407.

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