Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Trump administration unveils drug pricing initiative

American Patients First

The White House wants doctors to provide information about the out-of-pocket costs of prescription drugs and competing drugs.

Price transparency is a key theme to the broad package of proposals called American Patients First that the White House released May 11.

The administration is considering requiring a drug’s list prices to be included in all direct-to-consumer advertising.

The plan also calls for the banning of gag rules that prevent pharmacists from alerting patients when it would be cheaper to buy a prescribed drug without going through their insurance coverage, as well as moving certain drugs from Medicare Part B to Medicare Part D to improve the government’s ability to negotiations for lower prices.

The overall strategy is laid out across four areas:

  • Increasing competition though policy measures that prevent manufacturers from gaming the patent system and promoting innovation and competition among biologics.
  • Improving negotiation abilities, including doing more with value-based purchasing; allowing for more substitution, especially in the case of single-source generics; and further examination of the competitive acquisition program for Part B.
  • Providing incentives to manufacturers to lower their list prices.
  • Lowering out-of-pocket costs.

Read the article.

This Week's Must Reads

Overall survival factor in metastatic ccRCC, Thiery-Vuillemin A et al. Clinical Genitourinary Cancer 2018; 16: e297-e305

High perirenal fat thickness predicts poor progression-free survival in patients with localized ccRCC, Huang H et al. Urologic Oncology: Seminars and Original Investigations 2018; 36: 157.e1-157.e6

AXL linked to worse outcome of metastatic RCCs treated with sunitinib, Zucca L E et al. Urologic Oncology: Seminars and Original Investigations 2018: 36; 11.e13-11.e21

Pathologic predictors in lymph node dissection of metastatic RCC, Chipollini J et al. Clinical Genitourinary Cancer 2018; 16: Pages e443-450.

Plated-lymphocyte ratio is correlated with poor prognosis in RCC, Wang Z et al. Clinica Chimica Acta; 2018; 480: 166-72.

Must Reads in Practice Management

Flat pricing of ibrutinib , Sales revenues at the potential expense of patient safety

Most oncologists discuss medical marijuana with patients, Braun I et al. J Clin Oncol. 2018 May 10. doi: 10.1200/JCO.2017.76.1221.

$800M cut proposed for Centers for Medicare & Medicaid Innovation, Proposed rescission of budget authority

Medicare Beneficiary Identifiers required for billing by 2019, New Medicare cards

Trump administration unveils drug pricing initiative, American Patients First