Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Survey indicates opioid prescriptions have decreased

Physicians' progress to reverse the nation's opioid epidemic. American Medical Association.

Key clinical point: Prescriptions for opioids decreased by 22% over the last 5 years and did so in all 50 states.

Major finding: Providers dispensed almost 56 million fewer opioid prescriptions in 2017 than they did in 2013. The total number of prescriptions fell from a total of nearly 252 million in 2013 to 196 million in 2017.

Study details: The number of health care professionals registered for prescription drug monitoring programs more than tripled as well.

Read the article.

This Week's Must Reads

Perioperative radiation therapy underused in elderly patients with soft tissue sarcomas, Venigalla S et al. Intl J Rad Oncology*Biology*Physics; September (102) 2018: 155-165. https://doi.org/10.1016/j.ijrobp.2018.05.019

Age, R0 resection, and adjuvant radiotherapy boost outcomes in myxofibrosarcoma, Boughzala-Bennadji R et al. Intl J Rad Oncology*Biology*Physics; October (102) 2018: 399-406. https://doi.org/10.1016/j.ijrobp.2018.05.055

Tumor size, invasion beyond subcutaneous fat predict adverse outcomes in undifferentiated pleomorphic sarcoma, Winchester D et al. J Am Acad Dermatol. Available online 19 May 2018 https://doi.org/10.1016/j.jaad.2018.05.022

High recurrence rate after pancreaticoduodenectomy for primary retroperitoneal sarcoma, Tseng W et al. European Journal of Surgical Oncology 2018 (44): June; 810-815.

Nivolumab, pembrolizumab successfully used in Kaposi sarcoma, Galanina et al. Cancer Immunol Res. 2018 Sept 7. doi: 10.1158/2326-6066.CIR-18-0121.

Must Reads in Practice Management

Feds move to streamline oversight of gene therapy, Collins FS and Gottlieb S. N Engl J Med. doi: 10.1056/NEJMp1810628

Better access means better survival for rural cancer patients, Unger JM et al. JAMA Network Open. 2018;1(4):e181235. doi: 10.1001/jamanetworkopen.2018.1235

Financial disclosures in oncology studies often incomplete, Wayant C et al. JAMA Oncol. 2018 Aug 30. doi: 10.1001/jamaoncol.2018.3738

Medicare ACO savings still possible without imposing penalties, McWilliams JM et al. N Engl J Med. doi: 10.1056/NEJMsa1803388

Burnout linked to lower quality patient care, Panagioti M et al. JAMA Intern Med. 2018 Sept 4. doi: 10.1001/jamainternmed.2018.3713.