Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Survey indicates opioid prescriptions have decreased

Physicians' progress to reverse the nation's opioid epidemic. American Medical Association.

Key clinical point: Prescriptions for opioids decreased by 22% over the last 5 years and did so in all 50 states.

Major finding: Providers dispensed almost 56 million fewer opioid prescriptions in 2017 than they did in 2013. The total number of prescriptions fell from a total of nearly 252 million in 2013 to 196 million in 2017.

Study details: The number of health care professionals registered for prescription drug monitoring programs more than tripled as well.

Read the article.

This Week's Must Reads

New model guides treatment decisions in mRCC, Armstrong AJ et al. Ann Oncol. 2018 Sep 10. doi: 10.1093/annonc/mdy406

mRCC: Jaw osteonecrosis increased with denosumab/antiangiogenics, Guillot A et al. Clin Genitourin Cancer. 2018 Sep 6. doi: 10.1016/j.clgc.2018.08.006.

Brazilian study: TKIs effective in clear cell RCC, Velho PI et al. J Glob Onc. 2018 Sep 10. doi: 10.1200/JGO.18.00073.

SBRT safe, effective in oligometastatic RCC, Franzese et al. J Urol. 2018 Sep 1. doi: 10.1016/j.juro.2018.08.049.

CRP levels and RCC prognosis, Nakayama T et al. Clin Genitourin Cancer. 2018 Aug 11. doi: 10.1016/j.clgc.2018.07.027.

Must Reads in Practice Management

Feds move to streamline oversight of gene therapy, Collins FS and Gottlieb S. N Engl J Med. doi: 10.1056/NEJMp1810628

Better access means better survival for rural cancer patients, Unger JM et al. JAMA Network Open. 2018;1(4):e181235. doi: 10.1001/jamanetworkopen.2018.1235

Financial disclosures in oncology studies often incomplete, Wayant C et al. JAMA Oncol. 2018 Aug 30. doi: 10.1001/jamaoncol.2018.3738

Medicare ACO savings still possible without imposing penalties, McWilliams JM et al. N Engl J Med. doi: 10.1056/NEJMsa1803388

Burnout linked to lower quality patient care, Panagioti M et al. JAMA Intern Med. 2018 Sept 4. doi: 10.1001/jamainternmed.2018.3713.