Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Survey indicates opioid prescriptions have decreased

Physicians' progress to reverse the nation's opioid epidemic. American Medical Association.

Key clinical point: Prescriptions for opioids decreased by 22% over the last 5 years and did so in all 50 states.

Major finding: Providers dispensed almost 56 million fewer opioid prescriptions in 2017 than they did in 2013. The total number of prescriptions fell from a total of nearly 252 million in 2013 to 196 million in 2017.

Study details: The number of health care professionals registered for prescription drug monitoring programs more than tripled as well.

Read the article.

This Week's Must Reads

Vanderbilt staging best for predicting overall survival in retroperitoneal sarcoma, Huggett B & Cates J. Modern Pathology; 5 Nov. 2018.

Older patients with ccRCC may respond better to treatment than younger patients, Feulner et al. Urol Oncol. 2018 Nov 23. doi: 10.1016/j.urolonc.2018.11.006.

Still no validated biomarkers to select RCC treatment, D’Avella C et al. Urol Oncol. 2018 Nov 23. doi: 10.1016/j.urolonc.2018.10.027

DSS of ccRCC patients lower with high hTERT, Zanjani LS et al. Pathology. 2018 Nov 19. doi: 10.1016/j.pathol.2018.08.019.

ccRCC with papillary features best classified as a rare morphologic variant of ccRCC, Alaghehbandan R et al. Ann Diagn Pathol. 2018 Nov 22. doi: 10.1016/j.anndiagpath.2018.11.004.

Must Reads in Practice Management open enrollment picks up in Week 2, Weekly enrollment snapshot on

Trump administration takes contradictory actions on ACA, A press statement issued on

Doctors raise concerns about administration's Part B drug plan, A CMS Fact Sheet on the ANPRM International Pricing Index Model for Medicare Part B Drugs