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Revised International Pediatric Non-Hodgkin Lymphoma Staging System

Expert panel publishes evidence-based system

An international multidisciplinary expert panel recently published a new staging system for pediatric non-Hodgkin lymphoma. The proposed system characterizes 4 stages:

Stage

Definition

I

A single tumor, excluding mediastinum and abdomen

II

A single, extranodal tumor with regional node involvement, 2 or more nodal areas on the same side of the diaphragm, or a completely resectable primary gastrointestinal tract tumor, with or without associated mesenteric node involvement

III

2 or more extranodal tumors above and/or below the diaphragm, 2 or more nodal areas above and below the diaphragm, intra-abdominal and retroperitoneal disease, including liver, spleen, kidney, and /or ovary localizations, regardless of degree of resection, with or without involving associated mesenteric nodes that are completely resectable, any paraspinal or epidural tumor, and a single bone lesion with concomitant involvement of extranodal or nonregional nodal sites

IV

Any of the stage I to III characteristics with initial involvement of the central nervous system, bone marrow, or both

Citation: Rosolen A, Perkins SL, Pinkerton CR, et al. Revised international pediatric non-Hodgkin lymphoma staging system. [published online ahead of print May 4, 2015]. J Clin Oncol. doi:10.1200/JCO.2014.59.7203.

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