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Link Between Vitamin D and Lymphoma Survival

Analysis of patients in SWOG and LYSA trials

Serum vitamin D levels may be a potentially modifiable factor associated with survival in follicular lymphoma (FL), according to an analysis of two cohort studies of patients with previously untreated FL.

Using baseline serum samples of 25-hydroxyvitamin D, investigators analyzed the adjusted progression-free survival (PFS) hazard ratio (HR) and overall survival HR for patients in SWOG and Lymphoma Study Association (LYSA) trials. In patients who were vitamin D deficient (<20 ng/mL in SWOG or <10 ng/mL in LYSA), the following PFS and overall survival HRs were as follows:

PFS

Survival

SWOG

1.97

4.16

LYSA

1.50

1.92

Citation: Kelly JL, Salles G, Goldman B, et al. Low serum vitamin D levels are associated with inferior survival in follicular lymphoma: a prospective evaluation in SWOG and LYSA studies. J Clin Oncol. 2015. pii: JCO.2014.57.5092.

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