Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Immediate Breast Reconstruction Likelihood Studied

Clin Breast Cancer; ePub 2017 Dec 6; Reddy, et al

Younger women with breast cancer were more likely than older women to undergo immediate breast reconstruction (IBR), according to a study involving >320,000 individuals. Additionally, tumor grade and radiation therapy were differentially linked with the likelihood of immediate breast reconstruction across patient age. Participants underwent mastectomy over a 14-year period ending in 2014. Investigators estimated the effect of age on IBR, and looked at the impact of tumor grade and radiation therapy. Among the results:

  • ~One-fourth of women underwent IBR.
  • Age was significantly linked with IBR.
  • Younger women were more likely to undergo reconstruction.
  • Tumor grade and radiation therapy altered the effect of age on IBR.

Citation:

Reddy K, Strassle P, McGuire K. The role of age, tumor grade, and radiation therapy on immediate post-mastectomy breast reconstruction. [Published online ahead of print December 6, 2017]. Clin Breast Cancer. doi:10.1016/j.clbc.2017.11.021.

This Week's Must Reads

Liquid biopsy aids assessment in advanced imatinib-resistant GIST, George S et al. ASCO 2018. Abstract 11511.

Rapid therapy changes fall short for metastatic GIST, Serrano-Garcia C et al. ASCO 2018, Abstract 11510.

Estimated conditional OS shows upfront TKI benefit in mRCC, Kang M et al. J Urol. 2018 June 22. doi: 10.1016/j.juro.2018.06.030

Indolent course found in rare clear cell papillary RCC , Chen W-J et al. J Chinese Med Assoc. 2018 July 20 doi: 10.1016/j.jcma.2018.04.005

Must Reads in Breast Cancer

Brain met outcomes similar for NSCLC, breast cancer patients, Cagney DN et al. JAMA Oncol. 2018 May 17. doi: 10.1001/jamaoncol.2018.0813.

Ketorolac during primary breast cancer surgery bettered diclofenac, Desmedt C et al. J Natl Cancer Inst. 2018 Apr 30. doi: 10.1093/jnci/djy042.

FDA Approves Lynparza for Certain Types of BC, FDA news release; 2018 Jan 12