Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

How Negative, Positive Life Events Impact BC Risk

Clin Breast Cancer; ePub 2017 Nov 1; Fischer, et al

Negative life events appear to play a role in risk of breast cancer, according to a case-control study involving >860 individuals. Meanwhile, positive events may attenuate negative event effects. Participants included patients with breast cancer (n=664) and population-based controls (n=203). They completed a risk factor questionnaire that included queries about life events. Among the results:

  • Negative life events were linked with increased breast cancer risk.
  • Patients with ≥4 negative events had a nearly 3-fold increased risk of breast cancer.
  • Having a prior illness increased breast cancer risk by >3-fold.
  • Having an abortion was linked with a 45% decreased risk of breast cancer.
  • While positive life events did not have a significant impact on breast cancer risk, they appeared to buffer the adverse impact of negative events.

Citation:

Fischer A, Ziogas A, Anton-Culver H. Negative valence life events promote breast cancer development. [Published online ahead of print November 1, 2017]. Clin Breast Cancer. doi:10.1016/j.clbc.2017.10.017.

This Week's Must Reads

Does Integrated Delivery Treatment Impact Cost? , J Oncol Pract; ePub 2018 Feb 13; Kaye, Min, et al

Anticancer Agent Dose Rounding Cost Impact Assessed, J Oncol Pract; ePub 2018 Feb 5; Fahrenbruch, et al

Employment in Patients with Early-Stage BC Studied , Cancer; ePub 2018 Feb 13; Ekenga, Pérez, et al

Program’s Impact on CRC Screening in Uninsured , Cancer; ePub 2018 Feb 7; Eberth, Thibault, et al

Charting the Landscape of Oncology Pathway Vendors , J Oncol Pract; ePub 2018 Feb 7; Daly, Zon, et al

Must Reads in Breast Cancer

FDA Approves Lynparza for Certain Types of BC, FDA news release; 2018 Jan 12

Stereotactic Radiotherapy System Approved For BC, FDA news release; 2017 Dec 22

Perjeta Approved for Certain Type of Early BC, Genentech news release; 2017 Dec 20

Do Women with BC Use Their Pain Meds Correctly?, J Pain Symptom Manage; ePub 2017 Dec 5; Stephenson, et al

Immediate Breast Reconstruction Likelihood Studied, Clin Breast Cancer; ePub 2017 Dec 6; Reddy, et al