Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Partial nephrectomy is even more critical in early-onset RCC, Clemmensen T et al. Human Pathology April 2018 25-31. https://doi.org/10.1016/j.humpath.2017.11.005

PD-L1 status and aggressive clear cell RCC, Lopez J et al. Annals of Diagnostic Pathology June 2018, Pages 89-93 https://doi.org/10.1016/j.anndiagpath.2018.03.007

BAP1, PBRM1, and metabolic pathway changes correlate with RCC subtype-specific survival, Ricketts C et al. Cell Reports April 2018, Pages 313–326.e5 https://doi.org/10.1016/j.celrep.2018.03.075

RCCs more than 50% cystic have good prognosis, Kashan M et al. The Journal of Urology 1 March 2018 https://doi.org/10.1016/j.juro.2018.02.3087

Stereotactic radiosurgery yields higher overall survival in patients with RCC metastatic to the brain, Haque W et al. Clinical Genitourinary Cancer 3 April 2018 https://doi.org/10.1016/j.clgc.2018.03.015

Gastroenterology

Fiber Intake and Survival After CRC Diagnosis, JAMA Oncol; ePub 2017 Nov 2; Song, Wu, et al

Cochrane on Detecting CRC in Patients with IBD, Cochrane; 2017 Sep 18; Bye, Nguyen, Parker, et al

Read more in Gastroenterology

Melanoma

FDA Approves First Treatment for Rare Skin Cancer, FDA news release; 2017 Mar 23

High-Dose Interferon vs Observation for Melanoma , J Clin Oncol; ePub 2017 Jan 30; Agarwala, et al

Read more in Melanoma

Lung Cancer

Health Disparities in Elderly with NSCLC Studied, Cancer; ePub 2018 Jan 8; Cassidy, Zhang, et al

Barriers to Combo Therapy for Limited-Stage SCLC , JAMA Oncol; ePub 2018 Jan 4; Pezzi, et al

Read more in Lung Cancer

Practice Management

Right-to-try bill advances in Congress, The Trickett Wendler, Frank Mongiello, Jordan McLinn, and Matthew Bellina Right To Try Act of 2018 (H.R. 5247)

Best states to practice medicine are in the upper Midwest, Published online March 27 at https://wallethub.com/edu/best-and-worst-states-for-doctors/11376/#

Read more in Practice Management

Preventive Care

Predicting Acute Kidney Injury Risk from Cisplatin , J Clin Oncol; ePub 2018 Jan 10; Motwani, et al

ASCO Guideline on Alcohol Consumption and Cancer, J Clin Oncol; 2018 Jan; LoConte, Brewster, et al

Read more in Preventive Care