Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

This Week's Must Reads

Risk categories predict mRCC survival, Rini B et al. Clin Genitourin Cancer. 2018 May 3. doi: 10.1016/j.clgc.2018.04.005.

Access to care linked to better outcomes in black men with prostate cancer, Halabi et al, George et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology) Abstracts LBA5005 and LBA5009.

Prostate cancer before age 55 more likely in black men, Nettey OS et al. AUA 2018 (American Urological Association annual meeting). Abstract MP 21-17.

Statins may affect prostate cancer microenvironment, Allott E et al. AUA 2018 (annual meeting of the American Urological Association), Abstract MP21-01.

Prostate cancer risks higher in smokers, Foerster B et al. JAMA Oncol. 2018 May 24. doi: 10.1001/jamaoncol.2018.1071.

Clinical Guidelines

ASCO Guideline on Alcohol Consumption and Cancer, J Clin Oncol; 2018 Jan; LoConte, Brewster, et al

ASCO Updates Guideline on Role of BMAs in BC, J Clin Oncol; ePub 2017 Oct 16; Van Poznak, et al

Read more in Clinical Guidelines

FDA Actions

Nivolumab plus ipilimumab approved for advanced RCC, FDA approves nivolumab plus ipilimumab combination for intermediate or poor-risk advanced renal cell carcinoma https://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm604685.htm

FDA Approves Lynparza for Certain Types of BC, FDA news release; 2018 Jan 12

Read more in FDA Actions

Lung Cancer

Atezolizumab boosts outcomes in squamous NSCLC, Jotte et al. ASCO 2018 Abstract LBA9000.

CT scans underused for lung cancer screens, Pham DC et al. ASCO 2018. Abstract 6504.

Read more in Lung Cancer

Patient & Survivor Care

Head and neck cancer therapy toxicities greater in women, Cristina V et al. JAMA Oncol. 2018 May 24. doi: 10.1001/jamaoncol.2018.1080.

Colorectal cancer costs twice as much in US as Canada, Yezefski et al. ASCO 2018 Abstract LBA3579.

Read more in Patient & Survivor Care

Practice Management

Colorectal cancer costs twice as much in US as Canada, Yezefski et al. ASCO 2018 Abstract LBA3579.

Flat pricing of ibrutinib , Sales revenues at the potential expense of patient safety https://cancerletter.com/articles/20180413_5/

Read more in Practice Management

Head & Neck Cancers

Head and neck cancer therapy toxicities greater in women, Cristina V et al. JAMA Oncol. 2018 May 24. doi: 10.1001/jamaoncol.2018.1080.

CYCORE reduces radiotherapy side effects in head and neck cancers, Peterson et al. ASCO 2018, Abstract 6063

Read more in Head & Neck Cancers

Preventive Care

Predicting Acute Kidney Injury Risk from Cisplatin , J Clin Oncol; ePub 2018 Jan 10; Motwani, et al

ASCO Guideline on Alcohol Consumption and Cancer, J Clin Oncol; 2018 Jan; LoConte, Brewster, et al

Read more in Preventive Care

Breast Cancer

Brain met outcomes similar for NSCLC, breast cancer patients, Cagney DN et al. JAMA Oncol. 2018 May 17. doi: 10.1001/jamaoncol.2018.0813.

Read more in Breast Cancer

Genitourinary Cancer

Access to care linked to better outcomes in black men with prostate cancer, Halabi et al, George et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology) Abstracts LBA5005 and LBA5009.

Statins may affect prostate cancer microenvironment, Allott E et al. AUA 2018 (annual meeting of the American Urological Association), Abstract MP21-01.

Read more in Genitourinary Cancer

Leukemia, Myelodysplasia, Transplantation

Predicting CLL Prognosis, Can sequencing identify prognostic markers?

Genes Linked to Better Outcomes in AML , SWOG study identifies mutation linked to improved survival

Read more in Leukemia, Myelodysplasia, Transplantation

Renal Cell Carcinoma

Risk categories predict mRCC survival, Rini B et al. Clin Genitourin Cancer. 2018 May 3. doi: 10.1016/j.clgc.2018.04.005.

Access to care linked to better outcomes in black men with prostate cancer, Halabi et al, George et al. ASCO 2018 (annual meeting of the American Society of Clinical Oncology) Abstracts LBA5005 and LBA5009.

Read more in Renal Cell Carcinoma