Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Birth Defects and US Women with Zika Virus

JAMA; ePub 2016 Dec 15; Honein, Dawson, et al

Among pregnant US women who completed pregnancies with laboratory evidence of possible recent Zika virus infection, 6% of fetuses or infants had evidence of Zika-associated birth defects, primarily brain abnormalities and microcephaly, a recent study found. The study included 442 US women (median age, 28 years) with completed pregnancies and maternal, fetal, or infant laboratory evidence of possible Zika infection from January 15 to September 22, 2016. Researchers also found:

  • Of the 26 affected fetuses or infants, 4 had microcephaly and no reported neuroimaging, 14 had microcephaly and brain abnormalities, and 4 had brain abnormalities without microcephaly.
  • There were 21 infants with birth defects among 395 live births and 5 fetuses with birth defects among 47 pregnancy losses.
  • Among women with first-trimester Zika infection, 11% of fetuses or infants had evidence of Zika-associated birth defects.
  • There were no reports of birth defects among fetuses or infants with prenatal exposure to Zika virus infection only in the second or third trimesters.

Citation:

Honein MA, Dawson AL, Petersen EE, et al. Birth defects among fetuses and infants of US women with evidence of possible Zika virus infection during pregnancy. [Published online ahead of print December 15, 2016]. JAMA. doi:10.1001/jama.2016.19006.

This Week's Must Reads

Low-Dose Aspirin Use During Pregnancy, Obstet Gynecol; ePub 2018 Jul; ACOG, SMFM

Postpartum Pain & Fatigue Management , Obstet Gynecol; ePub 2018 Jul; ACOG

Vaginal Preparation Before Cesarean Section, Cochrane Library; ePub 2018 Jul 17; Haas, et al

Maternal Outcomes by Race in Women Aged ≥40 Years, Obstet Gynecol; ePub 2018 Jul 10; Booker, et al

Orilissa Approved for Pain Management of Endometriosis, AbbVie news release; 2018 July 24

Must Reads in Zika

Assessment of Fetuses & Infants Infected with Zika, Am J Obstet Gynecol; ePub 2018 Jan 15; Cortes, et al

Updated Zika Guidance for Pregnant Women, MMWR; ePub 2017 Jul 24; Oduyebo, et al

Evaluating Zika Virus Risk in Pregnancy, Obstet Gynecol; ePub 2017 May 5; Rao, Gaw, et al

Infant Outcomes in Women with Zika During Pregnancy, Am J Obstet Gynecol; ePub 2017 Jan 30; Adhikari, et al

Birth Defects and US Women with Zika Virus , JAMA; ePub 2016 Dec 15; Honein, Dawson, et al