Congenital microcephaly is not an optimal screening method for congenital Zika virus (ZIKV) syndrome, as it may not accompany other evident and preceding brain findings, a recent study found. The longitudinal cohort of ZIKV-infected pregnancies focused on clinical and imaging findings of patients with laboratory-confirmed ZIKV infection and fetal brain anomalies. Patients underwent monthly fetal ultrasound scans, neurosonography, and a fetal MRI. Researchers found:
- All 214 subjects had been referred for ZIKV symptoms during pregnancy affecting themselves or their partners or if fetal anomalies compatible with congenital ZIKV syndrome were detected.
- 12 pregnant patients with laboratory confirmation of ZIKV infection were diagnosed with fetal brain malformations.
- The most common findings assessed by prenatal and postnatal imaging were: brain volume loss (92%), calcifications (92%), callosal anomalies (100%), cortical malformations (89%), and ventriculomegaly (92%).
- Microcephaly was present in 33.3 to 58.3% of the cases at referral and present at delivery in 55.6 to 77.8% of cases.
Cortes MS, Rivera AM, Yepez M, et al. Clinical assessment and brain findings in a cohort of mothers, fetuses and infants infected with Zika virus. [Published online ahead of print January 15, 2018]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2018.01.012.
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