Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Depression Among Women of Childbearing Age

Obstet Gynecol; ePub 2018 Mar 8; Guo, et al

Approximately 5% of US women of childbearing age have symptoms of major depression, with nearly one-third of women with severe symptoms reporting antidepressant use. This according to a cross-sectional study of 3,705 nonpregnant women of childbearing age from the National Health and Nutrition Examination Surveys 2007-2014. The primary outcome is the prevalence of major depression, and secondary outcomes are the prevalence of minor depression, rates of antidepressant use, and predictors of major and minor depression. Researchers found:

  • The overall prevalence of major and minor depression was 4.8% and 4.3%, respectively.
  • The prevalence of antidepressant use among women with major depression and minor depression were 32.4% and 20.0%, respectively.
  • Factors most strongly associated with major depression were government insurance and hypertension; for minor depression, education less than high school or high school education.


Guo N, Robakis T, Miller C, Butwick A. Prevalence of depression among women of reproductive age in the United States. [Published online ahead of print March 8, 2018]. Obstet Gynecol. doi:10.1097/AOG.0000000000002535.

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