Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Vascular Dysfunction During Menopausal Transition

Menopause; ePub 2018 Apr 9; Hildreth, et al

Vascular dysfunction across the stages of menopause is associated with greater frequency and severity of menopausal symptoms and lower quality of life, but not depression, according to a recent study. Researchers measured arterial stiffness, endothelial function, menopausal symptoms, depression, and quality of life (QOL) in 138 premenopausal women. They found:

  • Menopausal symptoms, depression, and QOL worsened across menopause stages, particularly in late perimenopausal women.
  • Vasosomatic symptom frequency and general somatic symptom frequency and severity were inversely correlated with carotid artery compliance and FMD.
  • Only correlations with general somatic symptoms were significant after adjusting for multiple comparisons.
  • Total QOL was positively correlated with carotid artery compliance.

Citation:

Hildreth KL, Ozemek C, Kohrt WM, Blatchford P, Moreau KL. Vascular dysfunction across the stages of the menopausal transition is associated with menopausal symptoms and quality of life. [Published online ahead of print April 9, 2018]. Menopause. doi:10.1097/GME.0000000000001112.

This Week's Must Reads

Low-Dose Aspirin Use During Pregnancy, Obstet Gynecol; ePub 2018 Jul; ACOG, SMFM

Postpartum Pain & Fatigue Management , Obstet Gynecol; ePub 2018 Jul; ACOG

Vaginal Preparation Before Cesarean Section, Cochrane Library; ePub 2018 Jul 17; Haas, et al

Maternal Outcomes by Race in Women Aged ≥40 Years, Obstet Gynecol; ePub 2018 Jul 10; Booker, et al

Orilissa Approved for Pain Management of Endometriosis, AbbVie news release; 2018 July 24

Must Reads in Menopause

Cardiac Autonomic Function in Midlife Women, Menopause; ePub 2018 Jun 18; Fu, et al

Vasomotor Symptoms in Older Women, Menopause; ePub 2018 May 7; David, et al

Estrogen-alone Therapy & Invasive Breast Cancer, Menopause; ePub 2018 May 7; Shufelt, et al

Vascular Dysfunction During Menopausal Transition, Menopause; ePub 2018 Apr 9; Hildreth, et al

Menopausal HT & Hyperkyphosis Prevention , Menopause; ePub 2018 Feb 16; Woods, et al