Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

CV and Metabolic Morbidity After Hysterectomy

Menopause; ePub 2017 Dec 28; Laughlin-Tommaso, et al

Hysterectomy is associated with an increased long-term risk of cardiovascular (CV) and metabolic conditions, even with ovarian conservation, a recent study found. This risk is elevated in women who undergo hysterectomy at age ≤35 years. 2,094 women who underwent hysterectomy with ovarian conservation for benign indications between 1980 and 2002 in Olmsted County, MN, were included with each age-matched to a referent women residing in the same country who had not undergone prior hysterectomy or any oophorectomy. Researchers found:

  • Over a median follow-up of 21.9 years, women who underwent hysterectomy experienced increased risk of de novo hyperlipidemia (HR, 1.14), hypertension (HR, 1.13), obesity (HR, 1.18), cardiac arrhythmias (HR, 1.17), and coronary artery disease (CAD) (HR, 1.33).
  • Women who underwent hysterectomy at age ≤35 years had a 4.6-fold increased risk of congestive heart failure and a 2.5-fold increased risk of CAD.


Laughlin-Tommaso S, Khan Z, Weaver AL, Smith CY, Rocca WA, Stewart EA. Cardiovascular and metabolic morbidity after hysterectomy with ovarian conservation: a cohort study. [Published online ahead of print December 28, 2017]. Menopause. doi:10.1097/GME.0000000000001043.

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