Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Endometrial Cancer Risk with Aspirin Use

Gynecol Oncol; 2018 Jan; Takiuchi, Blake, et al

The benefits of aspirin therapy may exceed the potential risk in women with endometrial cancer despite conflicting findings according to a recent review that examined aspirin use and endometrial cancer risk and survival. Researchers reviewed the evidence for the association between endometrial cancer and obesity, the pharmacological differences between regular- and low-dose aspirin, as well as the potential anti-tumor mechanism of aspirin. Among their conclusions:

  • Aspirin was shown to have chemo-preventive effects on colorectal cancer.
  • Aspirin can suppress platelet activation.
  • Aspirin can indirectly inhibit prostaglandin E2, an obesity-related inflammatory marker.
  • Aspirin may improve the survival of women with endometrial adenocarcinoma.
  • Aspirin use may have a secondary benefit for obesity-related comorbidities including cardiovascular disease in this study population.


Takiuchi T, Blake EA, Matsuo K, Sood AK, Brasky TM. Aspirin use and endometrial cancer risk and survival. Gynecol Oncol. 2018;148:222-232. doi:10.1016/j.ygyno.2017.10.026.

This Week's Must Reads

Low Dose Aspirin and Spontaneous Preterm Birth, Am J Obstet Gynecol; ePub 2018 Jun 15; Andrikopoulou, et al

New Persistent Opioid Use After Hysterectomy, Am J Obstet Gynecol; ePub 2018 Jun 18; Swenson, et al

Salpingectomy at Time of Cesarean Delivery, Contraception; ePub 2018 Jun 20; Lehn, et al

Cardiac Autonomic Function in Midlife Women, Menopause; ePub 2018 Jun 18; Fu, et al

ACOG Recommendations for Maternal Immunization, Obstet Gynecol; ePub 2018 Jun; Ault, Riley, et al

Must Reads in Gynecologic Cancer

Place of Death in Patients with Gynecologic Cancer, Obstet Gynecol; ePub 2018 May 7; Hicks-Courant, et al

Recent IUD Use and Risk of Cervical Cancer, Contraception; ePub 2018 Apr 16; Averbach, et al

Occult Gynecologic Cancer in Hysterectomy or Myomectomy, Obstet Gynecol; ePub 2018 Mar 8; Desai, et al

Concomitant POPUI Procedures & Gynecologic Cancer Surgery, Female Pelvic Med Reconstr Surg; ePub 2018 Apr 4; Bochenska, et al

USPSTF: Screening for Ovarian Cancer, JAMA; 2018 Feb 13; USPSTF, Grossman, et al