Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Missed Breast Cancers in High Risk MRI Screening

Breast Cancer Res Treat; ePub 2018 Jan 31; Vreemann, et al

Nearly one-third of cancers detected in a high-risk screening program are already visible at the last negative MRI scan, and even more in women without BRCA mutations. This according to a study that evaluated the frequency of missed cancers on breast MRI in women participating in a high-risk screening program. For each cancer detected, researchers determined whether an MRI scan was available, which was reported to be negative. They found:

  • Negative prior MRI scans were available for 131 breast cancers.
  • 31% of cancers were visible at the initially negative MRI scan and 34% of cancers showed a minimal sign.
  • The presence of a BRCA mutation strongly reduced the likelihood of visible findings in the last negative MRI.


Vreemann S, Gubern-Merida A, Lardenoije S, et al. The frequency of missed breast cancers in women participating in a high-risk MRI screening program. [Published online ahead of print January 31, 2018]. Breast Cancer Res Treat. doi:10.1007/s10549-018-4688-z.

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