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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Assessment of Fetuses & Infants Infected with Zika

Am J Obstet Gynecol; ePub 2018 Jan 15; Cortes, et al

Congenital microcephaly is not an optimal screening method for congenital Zika virus (ZIKV) syndrome, as it may not accompany other evident and preceding brain findings, a recent study found. The longitudinal cohort of ZIKV-infected pregnancies focused on clinical and imaging findings of patients with laboratory-confirmed ZIKV infection and fetal brain anomalies. Patients underwent monthly fetal ultrasound scans, neurosonography, and a fetal MRI. Researchers found:

  • All 214 subjects had been referred for ZIKV symptoms during pregnancy affecting themselves or their partners or if fetal anomalies compatible with congenital ZIKV syndrome were detected.
  • 12 pregnant patients with laboratory confirmation of ZIKV infection were diagnosed with fetal brain malformations.
  • The most common findings assessed by prenatal and postnatal imaging were: brain volume loss (92%), calcifications (92%), callosal anomalies (100%), cortical malformations (89%), and ventriculomegaly (92%).
  • Microcephaly was present in 33.3 to 58.3% of the cases at referral and present at delivery in 55.6 to 77.8% of cases.


Cortes MS, Rivera AM, Yepez M, et al. Clinical assessment and brain findings in a cohort of mothers, fetuses and infants infected with Zika virus. [Published online ahead of print January 15, 2018]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2018.01.012.

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Must Reads in Zika

Assessment of Fetuses & Infants Infected with Zika, Am J Obstet Gynecol; ePub 2018 Jan 15; Cortes, et al

Updated Zika Guidance for Pregnant Women, MMWR; ePub 2017 Jul 24; Oduyebo, et al

Evaluating Zika Virus Risk in Pregnancy, Obstet Gynecol; ePub 2017 May 5; Rao, Gaw, et al

Infant Outcomes in Women with Zika During Pregnancy, Am J Obstet Gynecol; ePub 2017 Jan 30; Adhikari, et al

Birth Defects and US Women with Zika Virus , JAMA; ePub 2016 Dec 15; Honein, Dawson, et al