Vitamin D levels were not associated with ovarian reserve in a large group of infertile women with a high prevalence of diminished ovarian reserve, a recent study found. The retrospective cohort study included 457 infertile women aged 21-50 years who had baseline hormone measurements. Primary outcomes included a statistical analysis to determine whether a relationship exists between antimüllerian hormone (AMH), FSH, and serum 250H-D levels. Researchers found:
- 16.2% of patients had vitamin D deficiency.
- AMH and FSH levels did not vary between women with vitamin D deficiency and those with normal levels.
- Receiver operating characteristic (ROC) analysis to determine if 250H-D levels are predictive of AMH showed areas under the ROC curves (AUC) for women aged <38 years to be 0.501, 0.554, and 0.511 for AMH threshold values of 0.5 ng/mL, 1.0 ng/mL, and 5.0 ng/mL, respectively.
- AUC values were 0.549, 0.545, and 0.557 ng/mL for women aged ≥38 years.
Shapiro AJ, Darmon SK, Barad DH, Gleicher N, Kushnir VA. Vitamin D levels are not associated with ovarian reserve in a group of infertile women with a high prevalence of diminished ovarian reserve. Fertil Steril. 2018;110(4):761-766. doi:10.1016/j.fertnstert.2018.05.005.