Clinical Edge

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Role of Vitamin D Intake & Serum Levels in Conception

Fertil Steril; ePub 2017 Jun 16; Fung, et al

Women with vitamin D intake below estimated average requirement and serum 25-hydroxyvitamin D levels at risk for inadequacy or deficiency may be less likely to conceive and may benefit from increased vitamin D intake, a recent study found. The study included 132 healthy, nulliparous women aged 18 to 39 years. Clinical pregnancy and live birth were compared between those who did or did not meet the vitamin D estimated average requirement (EAR) intake of 10 µg/d and with serum 25-hydroxyvitamin D (25(OH)D) considered at risk for inadequacy or deficiency (≥50 nmol/L). Researchers found:

  • 37.1% of women in the study group did not meet the vitamin D EAR and 13.9% had serum levels at risk for inadequacy or deficiency.
  • Clinical pregnancies were significantly higher among women who met the vitamin D EAR and with sufficient serum 25(OH)D compared with those who did not.
  • Adjusted odds ratio of conceiving a clinical pregnancy was significantly higher among those who met the EAR (aOR, 2.26) and had sufficient serum 25(OH)D (aOR, 3.37).


Fung JL, Hartman TJ, Schleicher RL, Goldman MB. Association of vitamin D intake and serum levels with fertility: Results from the Lifestyle and Fertility Study. [Published online ahead of print June 16, 2017]. Fertil Steril. doi:10.1016/j.fertnstert.2017.05.037.