Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Preimplantation Genetic Screening in Donor Cycles

Am J Obstet Gynecol; ePub 2017 Jul 20; Barad, et al

Preimplantation genetic screening has not been associated with improved odds of live birth or reduction in miscarriage, according to a study that looked at donor oocyte-recipient cycles in the US. The retrospective cross-sectional study between 2005 and 2013 evaluated pregnancy and live birth rates in donor oocyte-recipient cycles after the first embryo transfer with day 5/6 embryos. Live birth rates in 392 preimplantation genetic screening and 20,616 control cycles were compared. Researchers found:

  • Overall, pregnancy and live birth rates were significantly lower in preimplantation genetic screening cycles compared to control cycles.
  • Adjusted odds of live birth for preimplantation genetic screening cycles were reduced by 35% (OR, 0.65).


Barad DH, Darmon SK, Kushnir VA, Albertini DF, Gleicher N. Impact of preimplantation genetic screening on donor oocyte-recipient cycles in the United States. [Published online ahead or print July 20, 2017]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2017.07.023.

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