Clinical Edge

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Maternal Beverage Intake and IVF Outcomes

Fertil Steril; ePub 2017 Oct 4; Machtinger, et al

In women undergoing in vitro fertilization (IVF), sugared beverages, independent of their caffeine content, may be a bigger obstacle to reproductive success than caffeine and caffeinated beverages without added sugar, a recent study found. The prospective study included 340 women undergoing IVF from 2014 through 2016 for infertility as well as for pregenetic diagnosis for autosomal recessive diseases enrolled during ovarian stimulation. They completed a questionnaire describing their usual beverage consumption. Researchers found:

  • Higher intake of sugared soda was associated with lower total, mature, and fertilized oocytes and quality embryos after ovarian stimulation.
  • Compared with women who did not drink sugared soda, the adjusted difference in percent of cycles resulting in live birth for women consuming 0.1-1 cups/day and >1 cup/day were –12% and –16%, respectively.
  • There were no associations between consumption of coffee, caffeine, or diet sodas and IVF outcomes.


Machtinger R, Gaskins AJ, Mansur A, et al. Association between preconception maternal beverage intake and in vitro fertilization outcomes. [Published online ahead of print October 4, 2017]. Fertil Steril. doi:10.1016/j.fertnstert.2017.09.007.