Clinical Edge

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Infertility, Metabolic Dysfunction & CV Events

Fertil Steril; ePub 2018 Nov 17; Gleason, et al

The experience of infertility at any point in a women’s reproductive lifecycle may be associated with later-life cardiovascular (CV) health, a recent study found. In a cross-sectional analysis among US women from the National Health and Nutrition Examination Survey (2013-2014), researchers examined the association of self-reported infertility and metabolic syndrome and CV events, including congestive heart failure, coronary heart disease (CHD), heart attack, or stroke. Among the details:

  • 744 US women aged 20‒59 years participated in the study.
  • 15.7% reported ever experiencing infertility, 27.6% met the definition of metabolic syndrome, and 2.84% reported ever having a CV event.
  • Compared to women who had never experienced infertility, women who reported infertility had a 1.79 higher odds of reporting symptoms of metabolic syndrome and 1.83 times higher odds of having experienced a CV event.
  • Women with self-reported infertility also had 71% higher odds of reporting a CV event after controlling for metabolic syndrome.


Gleason JL, Shenassa ED, Thoma ME. Self-reported infertility, metabolic dysfunction, and cardiovascular events: A cross-sectional analysis among U.S. women. [Published online ahead of print November 17, 2018]. Fertil Steril. doi:10.1016/j.fertnstert.2018.10.009.