Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Fasting Glucose Levels & Reproductive History

Gynecol Endocrinol; ePub 2018 Jan 24; Wallace, et al

Fasting blood glucose trends over the life-course differ among women by reproductive history and race, a recent study found. The study aimed to assess for trends in fasting blood glucose levels across the life-course among a cohort of women by reproductive history: nulligravid women, and gravid women with and without a history of gestational diabetes mellitus (GDM). In 358 women fasting blood glucose measured after the last pregnancy (or after age 40 among nulligravid women) was compared across reproductive history groups in linear models adjusted for prepregnancy fasting blood glucose, body mass index, race, parity, and age at outcome measure. Researchers found:

  • After adjustments, mean fasting glucose after age 40 was not different between gravid women without GDM history and nullgravid women.
  • However, women with a history of GDM had mean fasting glucose 27 mg/dL greater than nullgravid women.
  • Black women with a history of GDM had disproportionately elevated mean fasting glucose after age 40.


Wallace ME, Bazzano L, Zhang C, Harville E. Fasting glucose concentrations and associations with reproductive history over 40 years of follow-up. [Published online ahead of print January 24, 2018]. Gynecol Endocrinol. doi: 10.1080/09513590.2018.1431771.

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