Clinical Edge

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Vitamin D supplements in pregnancy boost bone health in offspring

Key clinical point: High-dose vitamin D supplements in pregnancy can improve the bone health of offspring.

Major finding: At 6 years, children in the vitamin D group had an 8-g greater mean total-body-less-head bone mineral content, compared with those in the placebo group.

Study details: Prospective, randomized, double-blind, placebo-controlled trial of 623 pregnant Danish women and their 584 children.

Disclosures: The study was supported by The Lundbeck Foundation, the Ministry of Health, Danish Council for Strategic Research, and the Capital Region Research Foundation. The authors declared no conflicts of interest.


Brustad N et al. JAMA Pediatrics 2020 Feb 24. doi: 10.1001/jamapediatrics.2019.6083.