Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Risk of Pregnancy Loss & Ambient Air Pollution

Fertil Steril; ePub 2017 Nov 16; Ha, et al

Exposure to air pollution throughout pregnancy is associated with pregnancy loss, a recent study found. The cohort study included 343 singleton pregnancies with detailed protocols for ovulation and pregnancy testing. Researchers found:

  • The incidence of pregnancy loss was 28%.
  • An interquartile range increase in average whole pregnancy ozone (HR, 1.12) and particulate matter <2.5 ┬Ám (HR, 1.13) concentrations were associated with faster time to pregnancy loss.
  • Sulfate compounds also increased risk (HR, 1.58).
  • Last 2 weeks of exposures were not associated with loss.


Ha S, Sundaram R, Buck Louis GM, et al. Ambient air pollution and the risk of pregnancy loss: A prospective cohort study. [Published online ahead of print November 16, 2017]. Fertil Steril. doi:10.1016/j.fertnstert.2017.09.037.