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Risk of Neonatal Morbidity with Intrauterine Hyperoxemia

Obstet Gynecol; ePub 2017 Mar 6; Raghuraman, et al

There is a small but significantly increased risk of neonatal morbidity in acidemic neonates with intrauterine hyperoxemia compared to normoxemia, a recent study found. This secondary analysis of a prospective study of singleton, nonanomalous deliveries at or beyond 37 weeks of gestation from 2010 to 2014 included 7,789 patients with validated paired cord gases. Researchers found:

  • 106 (1.4%) patients had the composite neonatal morbidity.
  • No difference in composite neonatal morbidity in patients with and without intrauterine hyperoxemia was observed in the cohort.
  • Rate of acidemia was not significantly different in the 2 groups (1.9% vs 1.8%)
  • In stratified analysis, there was evidence of effect modification with a significant association between intrauterine hyperoxemia and neonatal morbidity in the presence of acidemia (41.2% vs 21.4%), but not in its absence.


Raghuraman N, Temming LA, Stout MJ, Macones GA, Cahill AG, Tuuli MG. Intrauterine hyperoxemia and risk of neonatal morbidity. [Published online ahead of print March 6, 2017]. Obstet Gynecol. doi:10.1097/AOG.0000000000001931.