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Pregnancy-Associated Hypertension & Offspring Health

Obstet Gynecol; ePub 2018 Jan 9; Rice, et al

Among women who deliver at term, pregnancy-associated hypertension is associated with higher systolic blood pressure (BP) in the offspring, a recent study found. The analysis was a prospective observational follow-up study from 2012 to 2013 of children born to women previously enrolled in a mild gestational diabetes mellitus (DM) treatment trial or nongestational DM observational study. Researchers examined 979 children at a median age of 7 years and fasting blood samples were taken to determine cardiometabolic risk factors. They found:

  • 23 (2%) children were born preterm from a hypertensive pregnancy, 73 (75) were born at term from a hypertensive pregnancy, 58 (6%) were born preterm from a normotensive pregnancy, and 825 (84%) were born at term from a normotensive pregnancy (reference group).
  • Mean adjusted systolic BP was significantly higher in children born at term to mothers who experienced pregnancy-associated hypertension vs those born at term to normohypertensive mothers.
  • This was not observed in the offspring from their measures of diastolic BP, BMI, waist circumference, homeostatic model assessment or insulin resistance, glucose, or lipids.


Rice MM, Landon MB, Varner MW, et al. Pregnancy-associated hypertension and offspring cardiometabolic health. [Published online ahead of print January 9, 2018]. Obstet Gynecol. doi:10.1097/AOG.0000000000002433.