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Pregnancy-Associated Hypertension & Offspring Health

Obstet Gynecol; ePub 2018 Jan 9; Rice, et al

Among women who deliver at term, pregnancy-associated hypertension is associated with higher systolic blood pressure (BP) in the offspring, a recent study found. The analysis was a prospective observational follow-up study from 2012 to 2013 of children born to women previously enrolled in a mild gestational diabetes mellitus (DM) treatment trial or nongestational DM observational study. Researchers examined 979 children at a median age of 7 years and fasting blood samples were taken to determine cardiometabolic risk factors. They found:

  • 23 (2%) children were born preterm from a hypertensive pregnancy, 73 (75) were born at term from a hypertensive pregnancy, 58 (6%) were born preterm from a normotensive pregnancy, and 825 (84%) were born at term from a normotensive pregnancy (reference group).
  • Mean adjusted systolic BP was significantly higher in children born at term to mothers who experienced pregnancy-associated hypertension vs those born at term to normohypertensive mothers.
  • This was not observed in the offspring from their measures of diastolic BP, BMI, waist circumference, homeostatic model assessment or insulin resistance, glucose, or lipids.

Citation:

Rice MM, Landon MB, Varner MW, et al. Pregnancy-associated hypertension and offspring cardiometabolic health. [Published online ahead of print January 9, 2018]. Obstet Gynecol. doi:10.1097/AOG.0000000000002433.