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Is Obstetric VTE Prophylaxis Use Increasing?

Obstet Gynecol; 2017 Aug; Mardy, Siddiq, et al

Use of venous thromboembolism (VTE) prophylaxis during antepartum and postpartum readmissions increased substantially in the US from 2006 to 2015 and varied based on region and risk factors, a recent study found. The retrospective cohort study analyzed temporal trends of mechanical and pharmacologic VTE prophylaxis for patients hospitalized for antepartum and postpartum indications from 2006 to 2015. A total of 662,740 antepartum and 105,361 postpartum readmissions were included in the analysis. Researchers found:

  • Between 2006 and 2015, use of VTE prophylaxis increased from 18.5% to 38.7% for antepartum admissions and from 22.5% to 30.6% for postpartum readmissions.
  • Among women readmitted postpartum, 56.4% of prophylaxis was pharmacologic and 43.6% was mechanical.
  • For antepartum admissions, 87.2% of prophylaxis was mechanical and only 12.8% was pharmacologic.
  • Some risk factors for VTE were associated with lower rates of prophylaxis.
  • Use of VTE prophylaxis was most common in the South.


Mardy AH, Siddiq Z, Ananth CV, Wright JD, D’Alton ME, Friedman AM. Venous thromboembolism prophylaxis during antepartum admissions and postpartum readmissions. Obstet Gynecol. 2017;130(2):270-278. doi:10.1097/AOG.0000000000002099.