Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

NSAID Administration & Postpartum Blood Pressure

Obstet Gynecol; ePub 2018 Nov 5; Anastasio, et al

In women with hypertensive disorders of pregnancy, nonsteroidal anti-inflammatory drug (NSAID) drug administration is not associated with increased blood pressure (BP), a recent study found. Researchers conducted a retrospective cohort study in which patients were analyzed in 2 groups according to whether they received NSAIDs postpartum. The primary outcome was change in mean arterial pressure during the postpartum period. They found:

  • 276 women with hypertensive disorders of pregnancy were included (129 NSAID-unexposed and 147 NSAID-exposed).
  • Postpartum NSAID administration was not associated with a statistically significant change in mean arterial pressure vs no NSAID administration.
  • No difference was observed between the cohorts in terms of need for initiation or increase in dose of antihypertensive agents or maternal readmission for hypertensive disorder.


Anastasio HB, Campbell LE, Buermeyer A, et al. Nonsteroidal anti-inflammatory drug administration and postpartum blood pressure in women with hypertensive disorders of pregnancy. [Published online ahead of print November 5, 2018]. Obstet Gynecol. doi:10.1097/AOG.0000000000002979.