Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

NSAID Administration & Postpartum Blood Pressure

Obstet Gynecol; ePub 2018 Nov 5; Anastasio, et al

In women with hypertensive disorders of pregnancy, nonsteroidal anti-inflammatory drug (NSAID) drug administration is not associated with increased blood pressure (BP), a recent study found. Researchers conducted a retrospective cohort study in which patients were analyzed in 2 groups according to whether they received NSAIDs postpartum. The primary outcome was change in mean arterial pressure during the postpartum period. They found:

  • 276 women with hypertensive disorders of pregnancy were included (129 NSAID-unexposed and 147 NSAID-exposed).
  • Postpartum NSAID administration was not associated with a statistically significant change in mean arterial pressure vs no NSAID administration.
  • No difference was observed between the cohorts in terms of need for initiation or increase in dose of antihypertensive agents or maternal readmission for hypertensive disorder.

Citation:

Anastasio HB, Campbell LE, Buermeyer A, et al. Nonsteroidal anti-inflammatory drug administration and postpartum blood pressure in women with hypertensive disorders of pregnancy. [Published online ahead of print November 5, 2018]. Obstet Gynecol. doi:10.1097/AOG.0000000000002979.

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