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Magnesium Sulfate Use in Obstetrics

An updated ACOG committee opinion

The American College of Obstetricians and Gynecologists (ACOG) Committee on Obstetric Practice Society for Maternal-Fetal Medicine has issued an updated committee opinion to reflect a limited, focused change in gestational age at which to consider tocolysis. Tocolysis is not recommended beyond 34 weeks of gestation, and it is generally not recommended before 24 weeks of gestation but may be considered based on individual circumstances at 23 weeks. The ACOG and the Society for Maternal-Fetal Medicine continue to support the short-term (usually <48 hours) use of magnesium sulfate in obstetric care for appropriate durations of treatment, which include the following:

• Prevention and treatment of seizures in women with preeclampsia or eclampsia.

• Fetal neuroprotection before anticipated early preterm (less than 32 weeks of gestation) delivery.

• Short-term prolongation of pregnancy (up to 48 hours) to allow for the administration of antenatal corticosteroids in pregnant women who are at risk of preterm delivery within 7 days.

Citation: Magnesium sulfate use in obstetrics. Committee opinion No. 652. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2016;127:e52-3.