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Low Dose Aspirin and Spontaneous Preterm Birth

Am J Obstet Gynecol; ePub 2018 Jun 15; Andrikopoulou, et al

Low dose aspirin is associated with a significant decrease in spontaneous preterm birth (PTB) at <34 weeks gestation in healthy nulliparous women without comorbidities, a recent study found. The secondary analysis of a randomized, placebo-controlled trial included 2,543 women; 1,262 (49.6%) received low dose aspirin and 1,281 (50%) placebo. Baseline characteristics were similar between groups, except for marital status. Researchers found:

  • The rate of spontaneous PTB <34 weeks was 1.03% and 2.34% in the low dose aspirin and placebo group, respectively.
  • Additionally, the rate of spontaneous PTB <37 weeks was 6.58% in low dose aspirin and 7.03% in the placebo group.
  • The rate of overall PTB <37 weeks was 7.84% in low dose aspirin and 8.2% in the placebo group.
  • After adjustment for clinically significant variables, there was a significant reduction in spontaneous PTB <34 weeks in the low dose aspirin group.

Citation:

Andrikopoulou M, Purisch SE, Handal-Orefice R, Gyamfi-Bannerman C. Low dose aspirin is associated with reduce spontaneous preterm birth in nulliparous women. [Published online ahead of print June 15, 2018]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2018.06.011.

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