Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Long-Acting Opioid Use During Delivery Hospitalizations

Obstet Gynecol; ePub 2018 Sep 7; Duffy, et al

Use of methadone and buprenorphine increased during delivery hospitalizations over a 9-year period, while receipt of other long-acting opioids decreased, a recent study found. Researchers analyzed the Perspective database to evaluate patterns of long-acting opioid use during delivery hospitalizations from January 2006 through March 2015. Medications evaluated included methadone, formulations including buprenorphine, and extended-release formulations of oxycodone, morphine, fentanyl, and other opioids. Among the findings:

  • The analysis included 2,994,630 delivery hospitalizations.
  • Use of long-acting opioids increased significantly during the study period from 457 to 844 per 100,000 deliveries.
  • Although buprenorphine and methadone use increased, use of other long-acting opioids decreased.
  • Risk for severe morbidity was significantly lower with buprenorphine or methadone compared with other long-acting opioids.


Duffy CR, Wright JD, Landau R, et al. Trends and outcomes associated with using long-acting opioids during delivery hospitalizations. [Published online ahead of print September 7, 2018]. Obstet Gynecol. doi:10.1097/AOG.0000000000002861.

This Week's Must Reads

Inflammatory Cytokines & Perinatal Depression, Am J Obstet Gynecol; ePub 2018 Dec 14; Miller, et al

Childbirth Delivery Mode & Pelvic Floor Disorders, JAMA; 2018 Dec 18; Blomquist, Muñoz, et al

Chronic Disease Risk with Vaginal Estrogen Use, Menopause; ePub 2018 Dec 17; Bhupathiraju, et al

Robotic-Assisted Gynecologic Surgery in Elderly Patients, Am J Obstet Gynecol; ePub 2018 Dec 14; Madden, et al

Fertility Treatment and Breastfeeding Outcomes , Am J Obstet Gynecol; ePub 2018 Dec 1; Barrera, et al

Must Reads in Obstetrics

Inflammatory Cytokines & Perinatal Depression, Am J Obstet Gynecol; ePub 2018 Dec 14; Miller, et al

ACOG Guidelines: Pregestational Diabetes Mellitus, Obstet Gynecol; ePub 2018 Dec; ACOG, et al

NSAID Administration & Postpartum Blood Pressure, Obstet Gynecol; ePub 2018 Nov 5; Anastasio, et al

Maternal Position in Women with Epidural Anesthesia, Cochrane Library; ePub 2018 Nov 9; Walker, et al

Progestogen for Prevention of Recurrent Miscarriage, Cochrane Database; ePub 2018 Oct 8; Haas, et al