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Long-Acting Opioid Use During Delivery Hospitalizations

Obstet Gynecol; ePub 2018 Sep 7; Duffy, et al

Use of methadone and buprenorphine increased during delivery hospitalizations over a 9-year period, while receipt of other long-acting opioids decreased, a recent study found. Researchers analyzed the Perspective database to evaluate patterns of long-acting opioid use during delivery hospitalizations from January 2006 through March 2015. Medications evaluated included methadone, formulations including buprenorphine, and extended-release formulations of oxycodone, morphine, fentanyl, and other opioids. Among the findings:

  • The analysis included 2,994,630 delivery hospitalizations.
  • Use of long-acting opioids increased significantly during the study period from 457 to 844 per 100,000 deliveries.
  • Although buprenorphine and methadone use increased, use of other long-acting opioids decreased.
  • Risk for severe morbidity was significantly lower with buprenorphine or methadone compared with other long-acting opioids.


Duffy CR, Wright JD, Landau R, et al. Trends and outcomes associated with using long-acting opioids during delivery hospitalizations. [Published online ahead of print September 7, 2018]. Obstet Gynecol. doi:10.1097/AOG.0000000000002861.