Higher concentrations of cerebrospinal fluid (CSF) are associated with perinatal depression, according to a recent study of women with a singleton gestation at term undergoing a scheduled cesarean. Researchers examined the association between perinatal depression and inflammatory cytokines in plasma, the association between perinatal depression and inflammatory cytokines in CSF, and the correlations between plasma and CSF inflammatory cytokines. Women were screened for depression and those with depressive symptomatology preferentially enrolled. They found:
- Of the 117 women who met inclusion criteria, 76 (65%) screened positive for depression.
- No significant associations between any of the plasma cytokines and perinatal depression were observed.
- Conversely, in multivariable analyses, higher CSF IL-1β, IL-23, and IL-33 concentrations were significantly associated with increased odds of perinatal depression.
Miller ES, Sakowicz A, Roy A, et al. Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression. [Published online ahead of print December 14, 2018]. Am J Obstet Gynecol. doi:10.1016/j.ajog.2018.12.015.