Elevated progesterone levels on the day of human chorionic gonadotropin (hCG) administration resulted in significant differences in ongoing pregnancy rates, according to a study of 2,458 couples undergoing intrauterine insemination. The study looked at ongoing pregnancy and miscarriage rates and determined:
• Progesterone concentrations were significantly higher given that the E2 concentration increased.
• Ongoing pregnancy rates were significantly decreased in women with progesterone levels higher than 1.1ng/mL.
• Miscarriage rates were similar to that of pregnancy rates.
Citation: Requena A, Cruz M, Pacheco A, et al. Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels. Fertility and Sterility [Published online ahead of print July 11, 2015]. Doi:10.1016/j.fertnstert.2015.06.026.