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hCG Administration and Pregnancy Rates

Elevated progesterone levels play role

Elevated progesterone levels on the day of human chorionic gonadotropin (hCG) administration resulted in significant differences in ongoing pregnancy rates, according to a study of 2,458 couples undergoing intrauterine insemination. The study looked at ongoing pregnancy and miscarriage rates and determined:

• Progesterone concentrations were significantly higher given that the E2 concentration increased.

• Ongoing pregnancy rates were significantly decreased in women with progesterone levels higher than 1.1ng/mL.

• Miscarriage rates were similar to that of pregnancy rates.

Citation: Requena A, Cruz M, Pacheco A, et al. Ongoing pregnancy rates in intrauterine insemination are affected by late follicular-phase progesterone levels. Fertility and Sterility [Published online ahead of print July 11, 2015]. Doi:10.1016/j.fertnstert.2015.06.026.