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Is GDM Associated with Neonatal Respiratory Morbidity?

Obstet Gynecol; ePub 2019 Jan 8; Werner, et al

Maternal gestational diabetes mellitus (GDM) is not associated with increased neonatal respiratory morbidity among women at high risk for late preterm birth, a recent study found. The secondary analysis of a randomized placebo-controlled trial in which women with singleton pregnancies at high risk for delivery between 34 0/7 and 36 5/7 weeks of gestation were allocated to betamethasone or placebo. The primary outcome was a composite outcome of neonatal respiratory morbidity in the first 72 hours of life. Among the details:

  • Of 2,831 women enrolled in the trial, 306 (10.8%) had GDM.
  • Women with GDM were significantly older and were more likely to be parous and to have hypertensive disorders of pregnancy vs those without GDM.
  • Neonates born to women with GDM were no more likely to meet the primary outcomes than those born to women without GDM, even after adjustments.


Werner EF, Romano ME, Rouse DJ, et al. Association of gestational diabetes mellitus with neonatal respiratory morbidity. [Published online ahead of print January 8, 2019]. Obstet Gynecol. doi:10.1097/AOG.0000000000003053.