Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Can Low Dose Aspirin Improve Reproductive Outcomes?

J Clin Endocrinol Metab; ePub 2017 Feb 3; Sjaarda, et al

Low-dose aspirin (LDA) may increase clinical pregnancy and live birth rates in women attempting conception and with elevated high sensitivity C-reactive protein (hsCRP) and prior pregnancy loss, a recent study found. This secondary analysis included 1,228 healthy women aged 18 to 40 years with 1 to 2 pregnancy losses actively attempting to conceive. Confirmed pregnancy, live birth, and pregnancy loss were compared between LDA and placebo, stratified by tertile of preconception, pre-intervention serum hsCRP. Researchers found:

  • Live birth rate occurred in 55% of women overall.
  • LDA increased live birth among high hsCRP women to 59%.
  • LDA did not affect clinical pregnancy or live birth in the low or mid-level hsCRP tertiles.
  • The lowest pregnancy and live birth rates occurred among the highest hsCRP tertile receiving placebo.


Sjaarda LA, Radin RG, Silver RM, et al. Preconception low-dose aspirin restores diminished pregnancy and live birth rates in women with low grade inflammation: A secondary analysis of a randomized trial. [Published online ahead of print February 3, 2017]. J Clin Endocrinol Metab. doi:10.1210/jc.2016-2917.